Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment: the prevention of shoulder problems trial (UK PROSPER)

Abstract Background Musculoskeletal shoulder problems are common after breast cancer treatment.There is some evidence to suggest that early postoperative exercise is safe and may improve shoulder function.We describe the development and delivery of a complex intervention for evaluation within a randomised controlled trial (RCT), designed to target

read more



Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a DUAL FUEL COOKER rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features.Methods In this study, single-cell RNA sequencing (scRNA-seq) was used to profile the distinct t

read more